Daniel Mathwin

PhD Student
University of Leeds

Daniel was born in Newcastle, Australia, where he studied a Bachelor of Science at the University of Newcastle where he developed a keen interest in organic chemistry and pharmaceutical science. After completing his bachelor’s degree, Daniel than moved to Melbourne to do Honours in Pharmaceutical Science at Monash University, which involved medicinal chemistry research to screen potential ligands for a target protein. While he found drug discovery very interesting, Daniel decided that he was more interested in the manufacturing of pharmaceuticals at large scale. To further explore this interest Daniel undertook a Master of Industrial Research at the University of Melbourne which involved a placement at CSIRO, Australia’s national science agency. The research project was focused on developing continuous flow synthesis for generic active pharmaceutical ingredients (APIs). After graduating from his Masters in 2022 then look abroad to further experience with manufacturing organic molecules in continuous flow, and thus initiated a PhD at The University of Leeds later that year. The PhD program is part of a Centre for Doctoral Training called Molecules to Product, where he is supervised by Dr Adam Clayton, Prof. John Blacker and Prof. Nikil Kapur and is additionally sponsored by Sterling Pharma Solutions. Daniel’s PhD project is focused on developing chemoenzymatic cascades in continuous flow, harnessing the power of enzymes to efficiently make complex molecules and seamlessly telescoping these reactions with other forms of chemical catalysis such as transition metals. A key component of the research is making the two forms of catalysis compatible using continuous liquid-liquid separators which have been developed at the University of Leeds.