Publications
2024
Boyall SL, Clarke H, Dixon T, Davidson RWM, Leslie K, Clemens G, Muller FL, Clayton AD, Bourne RA, Chamberlain TW
Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis. ACS Sustainable Chemistry & Engineering, 2024, 12, 15125-15133.
Dixon TM, Williams J, Besenhard MO, Howard R, Macgregor J, Peach P, Clayton AD, Warren NJ, Bourne R
Operator-free HPLC automated method development guided by Bayesian optimization. Digital Discovery, 2024, 3, 1591-1601.
DOI: 10.1039/D4DD00062E
Arshad Z, Blacker AJ, Chamberlain TW, Kapur N, Clayton AD, Bourne RA
Droplet microfluidic flow platforms for automated reaction screening and optimisation. Current Opinion in Green and Sustainable Chemistry, 2024, 48, 100940.
Shaw T, Clayton AD, Labes R, Dixon TM, Boyall S, Kershaw OJ, Bourne RA, Hanson BC
A self-optimised approach to synthesising DEHiBA for advanced nuclear reprocessing, exploiting the power of machine-learning. Reaction Chemistry & Engineering, 2024, 9, 426-438.
DOI: 10.1039/D3RE00357D
Aldulaijan N, Marsden JA, Manson JA, Clayton AD
Adaptive Mixed Variable Bayesian Self-Optimisation of Catalytic Reactions. Reaction Chemistry & Engineering, 2024, 9, 308-316.
DOI: 10.1039/D3RE00476G
2023
Clayton AD
Recent Developments in Reactor Automation for Multistep Chemical Synthesis. Chemistry-Methods, 2023, 3, e202300021.
Clayton AD, Pyzer-Knapp E, Purdie M, Jones M, Barthelme A, Pavey J, Kapur N, Chamberlain T, Blacker J, Bourne R
Bayesian Self-Optimization for Telescoped Continuous Flow Synthesis. Angewandte Chemie International Edition, 2023, 62, e202214511.
Mueller P, Vriza A, Clayton AD, May O, Govan N, Notman S, Ley SV, Chamberlain TW, Bourne R
Exploring the chemical space of phenyl sulfide oxidation by automated optimization. Reaction Chemistry & Engineering, 2023, 8, 538-542.
DOI: 10.1039/D2RE00552B
Kershaw OJ, Clayton AD, Manson JA, Barthelme A, Pavey J, Peach P, Mustakis J, Howard RM, Chamberlain TW, Warren NJ, Bourne RA
Machine learning directed multi-objective optimization of mixed variable chemical systems. Chemical Engineering Journal, 2023, 451, 138443.
2022
Avila C, Green C, Kossenjans M, Clayton AD, Sarda S, Bourne R, Kogej T, Cassani C, Mazuela J
Automated stopped-flow library synthesis for rapid optimisation and machine learning directed experimentation. Chemical Science, 2022, 13, 12087-12099.
DOI: 10.1039/D2SC03016K
Mueller P, Clayton AD, Manson J, Riley S, May OS, Govan N, Notman S, Vey SL, Chamberlain TW, Bourne RA
Automated Multi-Objective Reaction Optimisation: Which Algorithm Should I Use? Reaction Chemistry & Engineering, 2022, 7, 987-993.
DOI: 10.1039/D1RE00549A
2021
Power L, Clayton AD, Reynolds W, Hose D, Ainsworth C, Chamberlain TW, Nguyen BN, Bourne R, Kapur N, Blacker J
Selective Separation of Amines from Continuous Processes using Automated pH Controlled Extraction. Reaction Chemistry & Engineering, 2021, 6, 1806-1810.
DOI: 10.1039/D1RE00205H
Bayana M, Blacker AJ, Clayton AD, Jolley KE, Labes R, Taylor CJ, Reynolds W
A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase. Journal of Flow Chemistry, 2021, 11, 31-36.
2020
Clayton AD, Labes R, Blacker AJ
Combination of chemocatalysis and biocatalysis in flow. Current Opinion in Green and Sustainable Chemistry, 2020, 26, 100378.
Clayton AD, Schweidtmann AM, Clemens G, Manson JA, Taylor CJ, Niño CG, Chamberlain TW, Kapur N, John Blacker A, Lapkin AA, Bourne RA
Automated Self-Optimisation of Multi-Step Reaction and Separation Processes Using Machine Learning. Chemical Engineering Journal, 2020, 384, 123340.
Clayton AD, Power LA, Reynolds W, Ainsworth C, Hose DRJ, Jones MF, Chamberlain TW, Blacker AJ, Bourne RA
Self-Optimising Reactive Extractions: Towards the Efficient Development of Multi-Step Continuous Flow Processes. Journal of Flow Chemistry, 2020, 10, 199-206.
2019
Manson JA, Clayton AD, Gonzalez Niño C, Labes R, Chamberlain T, Blacker AJ, Kapur N, Bourne RA
A Hybridised Optimisation of an Automated Photochemical Continuous Flow Reactor. Chimia, 2019, 73, 817-822.
Clayton AD, Manson JA, Taylor CJ, Chamberlain TW, Taylor BA, Clemens G, Bourne RA
Algorithms for the self-optimisation of chemical reactions. Reaction Chemistry and Engineering, 2019, 4, 1545-1554.
DOI: 10.1039/C9RE00209J
Martínez-Carrión A, Howlett MG, Alamillo-Ferrer C, Clayton AD, Bourne RA, Codina A, Vidal-Ferran A, Adams RW, Burés J
Kinetic Treatments for Catalyst Activation and Deactivation Processes based on Variable Time Normalization Analysis. Angewandte Chemie International Edition, 2019, 58, 10189-10193.
2018
Schweidtmann AM, Clayton AD, Holmes N, Bradford E, Bourne RA, Lapkin AA
Machine learning meets continuous flow chemistry: Automated optimization towards the Pareto front of multiple objectives. Chemical Engineering Journal, 2018, 352, 277-282.
Doherty S, Knight JG, Backhouse T, Bradford A, Saunders F, Bourne RA, Chamberlain TW, Stones R, Clayton A, Lovelock K
Highly efficient aqueous phase reduction of nitroarenes catalyzed by phosphine-decorated PEG-modified polymer immobilized ionic liquid stabilized PdNPs. Catalysis Science and Technology, 2018, 8, 1454-1467.
DOI: 10.1039/C7CY02557B
2017
Chapman MR, Kwan MHT, King G, Jolley KE, Hussain M, Hussain S, Salama IE, González Nino C, Thompson LA, Bayana ME, Clayton A, Nguyen BN, Turner NJ, Kapur N, Blacker AJ
Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times. Organic Process Research & Development, 2017, 21, 1294-1301.
Abdulla O, Clayton AD, Faulkner RA, Gill DM, Rice CR, Walton SM, Sweeney JB
Catalytic sp3–sp3 Functionalisation of Sulfonamides: Late‐Stage Modification of Drug‐Like Molecules. Chemistry – A European Journal, 2017, 23, 1494-1497.